Gesiket
Human Drugs
Gesiket
Active Ingredient
Ketoprofen
Which is a nonsteroidal anti-inflammatory drug
Mechanism of Action
Gesiket has ketoprofen and the anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
Pharmacotherapeutic Group
potent non-steroidal anti-inflammatory agent.
Market Name
Gesiket
Dosage Form
Hard Gelatin Capsule
Each capsule contains 75 mg Ketoprofen
Indication
Carefully consider the potential benefits and risks of Gesiket 75mg capsules before deciding to use Gesiket 75 mg capsules.
Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Gesiket are indicated for
- the management of the signs and symptoms of rheumatoid arthritis and osteoarthritis.
- the management of pain.
- treatment of primary dysmenorrhea.
Contraindication
This Drug is contraindicated in patients who have shown hypersensitivity to ketoprofen.
This Drug should not be given to patients who have experienced asthma, urticaria, or allergic type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic reactions to ketoprofen have been reported in such patients.
This Drug is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
Pregnancy & Lactation
Pregnancy
Pregnancy Category C
There are no adequate and well controlled studies in pregnant women. Gesiket 75mg capsules should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.
Nursing Mothers
It is not known whether this drug is excreted in human milk. Data on secretion in human milk after ingestion of ketoprofen do not exist.
ketoprofen is not recommended for use in nursing mothers
Mechanism of Action
Gesiket has ketoprofen and the anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
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