Doradect Injectable solution

ActiveI ingredient

Doramectin

Product name

Doradect Injectable solution

Class

Broad-spectrum parasiticide

Market Name

Doradect

Dosage Form

Injectable solution

Indication

Cattle:

Doradect injectable solution is indicated for the treatment and control of the following species of gastrointestinal roundworms, eye worms, grubs, sucking lice and mange mites.

gastrointestinal roundworms (adult and fourth stage larvae) – ostertagia ostertagi (including inhibited larvae) , O.lyrata , Haemonchus placei , Trichostrongylus axei, T.colubriformis ,T. longispicularis , Cooperia oncophora , C. ectinata , C. punctata , C. surnabada , Bunostomum phlebotomum , Strongyloides papillosus , Oasophagostomum radiatum , Trichuris spp

Lungworms (adults and forth stage larvae) – Dictyocaulus viviparous

Eyeworms (adults) – Thelazia spp.

Grubs (parasitic stage) – hypoderma bovis, H. lineatum

Sucking lice – Haematopinus eurysternus, linognathus vituli, Solenopotes capillatus

Mange mites – Psoroptes bovis, Sarcoptes scabiei

Doradect injectable solution has been proved to effectively control infections and to protect cattle from reinfection with Cooperia oncophera and Haemonchus placei for 14 days, Ostertagia ostertagi for 21 days, and C. punctata, Oesophagostomum radiatum, and Dictyocaulus viviparous for 28 days after treatment.

Swine:

Doradect injectable solution is indicated for the treatment and control of the following species of gastrointestinal roundworms, lungworms, kidney worms, sucking lice, and mange mites.

Gastrointestinal roundworms (adults and fourth stage larvae) – Ascaris suum, Oesophagostomum dentatum, Oesophagostomum quadrispinulatum, Strongyloides ransomi, Hyostrongylus rubidus

Lungworms (adults) – Metastrongylus spp.

Kidney worms (adults) – Stephanurus Dentatum

Mange mites (adults and immature stages) – Sarcoptes scabiei var. suis

Sucking lice (adults and immature stages) – Haematopinus suis

Sheep:

Doradect injectable solution is indicated for the treatment and control of the roundworm, nasal bots

Contraindication ​​​​​​​

Do not use in dry dairy cows including pregnant dairy heifers within 60 days of calving.

Extra label use in dogs should be avoided, as severe adverse reactions may occur. In common with other avermectins, certain breeds of dog, such as collies, are especially sensitive to doramectin and particular care should be taken to avoid accidental consumption of the product.

Mechanism of Action

Mode of action of Macrocyclic lactone is to modulate chloride ion channel activity in the nervous system of nematodes and arthropods. Also bind to receptors that increase membrane permeability to chloride ions. This inhibits the electrical activity of nerve cells in nematodes and muscle cells in arthropods and causes paralysis and death of the parasites. In mammals, the neuronal receptors to which macrocyclic lactones bind are localized within the central nervous system, a site reached by only negligible concentrations of doramectin.