Ivectin 1% Injectable solution

Active Ingredient

Ivermectin 1gm

Product name

Ivectin 1% Injectable solution

Class

Anti-parasite medication   ANTHELMINTICS

Market Name

Ivectin 1% Injectable solution

Dosage Form

Injectable solution

Indication

For the effective treatment and control of the following harmful parasites of cattle, sheep and pigs:

Cattle

Gastrointestinal roundworms (adult and fourth-stage larvae):

Ostertagia spp. (including inhibited O. ostertagi), Haemonchus placei, Trichostrongylus axei, T. Colubriformis, Cooperia spp, Bunostomum phlebotomum

Oesophagostomum radiatum, Strongyloides papillosus (adult)                       Nematodirus helvetianus (adult), N. spathiger (adult), Trichuris spp (adult).

Lungworms (adult and fourth-stage larvae):

            Dictyocaulus viviparous

Eye worms (adult):

            Thelazia spp

Warbles:

            Hypoderma bovis, H. lineatum

Mange mites:

            Psoroptes bovis, Sarcoptes scabiei var. bovis 

Sucking lice:

            Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus

May also be used as an aid in the control of the mange mite Chorioptes bovis and biting lice Damalinia bovis, but complete elimination may not occur.

Sheep

Gastrointestinal roundworms (adult and fourth-stage larvae):

            Ostertagia circumcincta including inhibited larvae

            O. trifurcata

            Haemonchus contortus including inhibited larvae

            Trichostrongylus axei (adults)

            T. colubriformis and T. vitrinus (adults)

            Cooperia curticei

            Oesophagostomum columbianum

            O. venulosum (adults)

            Nematodirus filicollis

            Chabertia ovina

            Trichuris ovis (adults).

 Lungworms:

            Dictyocaulus filaria (adult and fourth-stage larvae)

            Protostrongylus rufescens (adults)

Nasal Bots (all larval stages)

             Oestrus ovis

Pigs

Gastrointestinal roundworms (adult and fourth-stage larvae):

            Ascaris suum

            Hyostrongylus rubidus

            Oesophagostomum spp.

            Strongyloides ransomi (adult and somatic larval stages)

Lungworms:

            Metastrongylus spp. (adults)

Lice:

            Haematopinus suis

Mange mites:

            Sarcoptes scabiei var. Suis

Contraindication

  Do not use in animals with known hypersensitivity to the active ingredient.

  Do not use by intramuscular or intravenous administration

  Do not use in dairy cows or sheep producing milk for human consumption

  Do not use in non-lactating dairy cows or sheep within 60 days of calving/lambing. 

Mechanism of Action

Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action.  Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.  This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.  Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).