MAMPHEDIN 5% Injectable solution
Veterinary Drugs
MAMPHEDIN 5% Injectable solution
Active Ingredient
Flunixin meglumine
Class
Non-steroidal anti-inflammatory drug
Market Name
MAMPHEDIN 5% Injectable solution
Dosage Form
Injectable solution
Indication
Cattle:
1-Control of acute inflammation associated with respiratory disease.
2-Mamphedin 5% has some benefit in the treatment of experimental acute bovine pulmonary emphysema (for fever).
3- Treatment of acute mastitis.
4- Provides effective anti-inflammatory and analgesic action in a wide range of musculoskeletal disorders
5- Used in the therapy of arthritis, myositis and traumatic injuries resulting in fractures and contusions.
6- Recommended as an adjunct to the treatment of persistent hyperthermia.
Pigs:
1-For use as an adjunctive therapy in the treatment of swine respiratory diseases.
2- Recommended as an adjunct to the therapy of Mastitis – Metritis – Agalactia (MMA) syndrome.
Horses:
1-For the alleviation of inflammation and pain associated with musculo-skeletal disorders.
2-For the alleviation of visceral pain associated with colic in the horse.
3-employed pre- and post- operatively to reduce inflammation resulting from intraocular surgery.
4- Administered subconjunctivally prior to intraocular surgery to reduce aqueous humor prostacyclin accumulation.
Dogs:
1- Provides effective anti-inflammatory and analgesic action in a wide range of musculoskeletal disorders
2- Used in the therapy of arthritis, myositis and traumatic injuries resulting in fractures and contusions
3- employed pre- and post- operatively to reduce inflammation resulting from intraocular surgery.
4- Administered subconjunctivally prior to intraocular surgery to reduce aqueous humor prostacyclin accumulation.
Contraindication
1-Do not use in cats.
2-Do not admix in syringe with other compounds.
3-Do not use concomitantly with other anti-inflammatory drugs, or with nephrotoxic substance.
4-Milk collected from cows within 36 hours (3 milking) following treatment must not be used for human consumption or processing.
Mechanism of Action
Flunixin meglumine is a non–steroidal anti-inflammatory agent with analgesic and antipyretic activity. It acts through inhibition of cyclooxygenase, blocks synthesis of eicosanoids, including prostaglandins, thromboxane, and prostacyclin (PGI2), which are chemical mediators of inflammation.
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