MAMIZOLE 12% Injectable solution
Veterinary Drugs
MAMIZOLE 12% Injectable solution
active ingredient
Imidocarb dipropionate
class
Antiprotozoal agent
market name
MAMIZOLE 12% Injectable solution
dosage form
Injectable solution
indication
For treatment and prevention of bovine (red water fever – babesia divergens infection) only.
Target spp: Cattle.
Contraindication
Mamizole must not be administered intravenously or intramuscularly.
Repeat doses of Mamizole must not be given.
Mechanism of action
Imidocarb dipropionate is a substituted carbinilide, used as an antiprotozoan treatment for the control of babesia spp. little is known about the mode –of- action of imidocarb dipropionate. It appears that imidocarb acts directly on the parasite, causing alteration in number and size of nuclei and in morphology (vacuolation) of the cytoplasm. The antiprotozoan activity is derived from the carbanilide acting on glycolyis of the parasite. This is the result of this class of drugs giving rise to hypoglycemia in the host. Babesia as well as many other parasites like trypanosomes depends upon host glucose for aerobic glycolysis. There is also a selective blocking effect on the replication of the quinetoplastic DNA of the parasite
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